(☼Director, *Executive Committee)

James Angelastro, Associate Professor, Molecular Biosciences -

Paul Ashwood, Professor, Microbiology and Immunology -

Deborah Bennett, Associate Professor, Public Health Sciences - Fate, transport, and exposure to chemicals in a multimedia environment within the context of environmental exposure and risk assessment. My work currently focuses on organic compounds in the indoor environment, including partitioning to the various surfaces in the home. Research techniques include both modeling approaches and measurement studies. Volatile organic compounds, pesticides, and flame retardants are emphasized.

Robert Berman, Professor, Neurological Surgery, Med - Mechanisms of brain injury and recovery, effects of prenatal drug exposure on brain growth and development, neuroplasticity, and brain mechanisms of learning and memory.

Sean Burgess, Professor, Molecular and Cellular Biology – Molecular mechanisms of chromosome organization and segregation during meiosis in yeast and zebrafish. Genetic and environmental effects resulting in aneuploidy and genome rearrangements.

Kermit Carraway, Professor, Biochemistry and Molecular Medicine - The lab uses biochemical, cell biological, pharmacological and genetic methods to dissect the roles of growth factors, their receptors and modulator proteins in mammalian development and in tumor initiation and progression. We are particularly interested in mechanisms of receptor ubiquitination and degradation, and how these processes impact the receptor overexpression that drives the malignancy of breast and brain tumors.

Frederic Chedin, Associate Professor, Molecular and Cellular Biology - Mammalian epigenetics.  I am interested in elucidating the molecular mechanisms that are responsible for setting up cytosine DNA methylation patterns in the human genome. How these mechanisms go awry in disease conditions, in particular in auto-immune disorders and cancer, is also of direct relevance to my work. To investigate these question, my group makes use of (epi)genomics tools, mammalian cell culture assays and biochemistry.

Hongwu Chen, Professor, Biochemistry and Molecular Medicine - Chromatin/epigenetic regulators in hormone signaling and in cancer

Xinbin Chen, Professor/Director, Surgical & Radiological Sciences, Vet Med - Genetic Regulation, Cancer & Carcinogenesis  

Gino Cortopassi, Professor, Molecular Biosciences, Vet Med – Biochemistry, bioenergetics, molecular genetics, aging and toxicology of mitochondria

Jacqueline Crawley, Professor, Psychiatry & Behavior Sciences, Robert E. Chason Endowed Chair in Translational Research, Med - Our laboratory employs mouse models to investigate the genes, biological mechanisms, and environmental factors causing behavioral abnormalities in neuropsychiatric and neurodevelopmental disorders.

Rosemary Cress,Associate Professor, Public Health Sciences, Epidemiology - Cancer epidemiology, ovarian and colorectal cancer, quality of cancer care, and health disparities.

*Sheila David, Professor, Chemistry - Nucleic acid chemistry and enzymology, DNA damage and repair

*Michael Denison, Professor, Environmental Toxicology, A&ES – Receptor-mediated mechanisms of action of environmental toxicants, especially halogenated aromatic hydrocarbons

Elva Diaz, Associate Professor, Pharmacology, - Functional genomics of nervous system development

Susan Ebeler, Professor, Viticulture and Enology, A&ES – Chemopreventive role of dietary polyphenols on tumor development

Dave Furlow, Professor, Neurobiology, Physiology and Behavior - Molecular basis of hormone action, particularly during development. Analysis of gene expression cascades during morphogenesis. Mechanisms of skeletal muscle atrophy and death.

Nilesh Gaikwad, Assistant Professor, Nutrition/Environmental Toxicology - Dr. Gaikwad’s research interests include: 1. Development of mass spectrometric analytical methods for comprehensive measurement of the small molecules in the cells/tissues/body fluids. 2. Development of biomarkers by applying target / profile oriented metabolomic methods. 3. Modulation of metabolic profile by using antioxidants, polyphenols, flavones and phytochemicals.

Ellen Gold, Professor, Public Health Sciences - Dr. Gold's research focuses on: 1. Lifestyle and other Factors Related to Hot Flashes and the Timing of Menopause 2. Lifestyle and Ovarian Function in Midlife Women 3. Endocrine and other Health Effects of Environmental Exposures in Women.

Tzipora Goldkorn, Professor, Pulmonary Medicine - Mechanisms of modulation of tyrosine kinase receptors interaction and stability. Stress modulation of sphingomyelin pathway and apoptosis. Regulation of AKT kinase and other survival factors, such as Bcl2 and NFkB. Molecular characterization of the membrane neutral sphingomyelinase that is regulated by oxidative stress. Ceramide target genes (microarrays). Ceramide mechanistic interactions with Bcl2, Caspases and mitochondria. Dietary sphingolipids in cancer

Fred Gorin, Professor, Neurology:  Med - Neuropharmacological research-drug design for brain tumor therapies, ion transporters and metablolism within the central nervous system. Basic neuroinformatics research using statistical methodologies for drug discovery and neurotoxicology.

Paul Hagerman, Professor, Biochemistry and Molecular Medicine -

Randi Hagerman, Professor, Medical Director of the MIND Institute - Her research focuses on the correlation between an individual's molecular genotype, or genetic make-up, and physical and behavioral characteristics, in addition to targeted treatments for Fragile X Syndrome and the fragile X-associated tremor ataxia syndrome (FXTAS).

Bruce Hammock, Distinguished Professor, Entomology and UC Davis Comprehensive Cancer Center, PI NIEHS Superfund Program, Director NIH Training in biotechnology – Mechanisms of action and degradation of xenobiotics of natural and synthetic origin. Medicinal chemistry and pharmacology of novel drugs for pain and inflammation. Role of dietary lipids in inflammation and cancer.  Biosensor development.  Mass spectrometry and metabolomics of lipid mediators.

Richart Harper, Associate Professor, UCDHS:  Pulmonary & Critical Care Medicine - Oxidant regulation of innate immunity in airway epithelium, and the molecular mechanisms responsible for oxidant-regulated signaling in the respiratory tract

Peter Havel, Professor, Nutrition and Molecular Biosciences -  

Irva Hertz-Picciotto, Professor, Public Health Sciences -

Wolf-Dietrich Heyer, Professor, Microbiology - DNA repair, recombination, and how DNA damage check point signaling contributes to the molecular basis for studies in genetic toxicology.

Neil Hunter, Professor, Microbiology and Molecular Genetics - Homologous Recombination. The mechanism and regulation of chromosome repair by homologous recombination and its role in chromosome transmission and genome stability.  Post-Translational Protein Modification in Meiosis. The nature and function of post-translational modifications of proteins involved in homologous recombination during meiosis.

Dallas Hyde, Professor, Anatomy, Physiology and Cell Biology, Vet Med – Lung-selective injury, especially the roles of chemokines and neutrophils

Lee-Way Jin, Professor, Pathology and Laboratory Medicine -  Autism spectrum disorders; Alzheimer's disease

Nicholas Kenyon, Professor, UCDHS:  Pulmonary & Critical Care Medicine - Environmental effects on lung function, the role of nitric oxide in airway diseases, asthma, COPD and lung injury

Michael Kleeman, Professor, Civil and Environmental Engineering - Epidemiology of fine and ultrafine particles, influence of emissions on air quality

Janine LaSalle, Professor, Microbiology & Immunology - Pathogenesis and epigenetics of human neurodevelopmental disorders

Pamela Lein, Professor, Molecular Biosciences - The role of inflammatory cells and cytokines in mediating the adverse effects of neurotoxic agents on the developing brain and altering nerve function in asthma

Helene Margolis, Associate Adjunct Professor, Internal Medicine: Division of General Medicine - Public health impacts of climate change and variability, including clinical ramifications and interventions to reduce vulnerability; pathophysiology/mechanisms and influence of environmental factors on natural history of chronic diseases (respiratory, cardiovascular, metabolic, immunologic); children’s environmental health; pediatric asthma and lung function growth; gene-environment interactions; exposure assessment; and translation of research findings into integrated public health and environmental policies.

*Lisa Miller, Associate Professor, Anatomy/Physiology and Cell Biology:  Vet Med -My research program is focused on understanding the relationship between early life environmental exposures, immunity and chronic disease.  We study how mucosal and systemic immunity is established during infancy, and determine the impact of air pollutants, allergens, and infectious disease on childhood health.  A major emphasis has been in the elucidation of mechanisms for immune susceptibility that lead to pediatric airways dysfunction, which may ultimately lead to generation of new diagnostics and preventative medicine.   

Patricia Oteiza, Professor, Nutrition - Characterization of the effect of trace mineral deficiencies and trace mineral toxicities on early development.

*Isaac Pessah, Professor, Molecular Biosciences, Vet Med – Mechanisms of calcium signal regulation and its perturbation by halogenated xenobiotics in neural development

Kent Pinkerton, Professor, Pediatrics, Med and Anatomy, Physiology and Cell Biology, Vet Med – Inhalation and respiratory toxicology, effects on lung growth, development, metabolism and disease.

Martin Privalsky, Professor, Microbiology - understanding how cells regulate their proliferation and differentiation and the aberrant events which lead to neoplasia

Birgit Puschner, Professor, Molecular Biosciences - Diagnostic Veterinary Toxicology; Poisonous Plants; Algal toxins; Natural toxins

*Robert Rice, Professor, Environmental Toxicology, A&ES – Differentiation of cultured human epidermal cells and its perturbation by metals (arsenic) and chlorinated aromatics (dioxin)

Marc Schenker, Professor, Public Health Sciences - Epidemiology of occupational and environmental diseases, focus on respiratory diseases, occupational cancer, reproductive hazards and agriculture/pesticide related diseases

Rebecca Schmidt, Assistant Professor, Public Health Sciences - My research goal is to advance understanding of how environmental exposures, primarily those occurring during gestation, interact with genetic susceptibility to influence neurodevelopmental outcomes for children, using a mechanistic and pathways perspective. Because nutritional factors, especially B-complex vitamins needed for one-carbon metabolism and methylation reactions, have prominent influences on gene expression and are especially important during gestation and early life, my research has largely focused their effects on neurodevelopment and risk for autism.

Taka Shibamoto, Professor, Environmental Toxicology, A&ES – Analysis of chemicals in food, including their roles in lipid peroxidation and their antioxidant activities

Swee Teh, Adjunct Professor, Anatomy, Physiology & Cell Biology : Vet Med - My goal is to develop an aquatic ecotoxicologyand endocrine disrupting chemicals screening program within the School of Veterinary Medicine. The Aquatic Toxicology Laboratory is state certified with greater than 20 years of experience investigating water quality and its impacts on the health of organisms. The Aquatic Health Program strives to promote and protect the well-being of all aquatic species and their environments by investigating the behavioral, anatomical, and physiological components of individual organisms and applying them to the ecosystem scale.

Ron Tjeerdema, Professor, Environmental Toxicology, A&ES – Fate and toxic actions of pesticides and petroleum products in aquatic organisms and systems

Judy Van de WaterProfessor, Rheum/Allergy - Immunopathology and the cellular and molecular basis of autoimmunity. Current research addresses the biological aspects of autism spectrum disorders including immune function, cellular mechanisms of immune dysregulation, and autoimmunity.

Laura Van Winkle, Adjunct Professor, Anatomy/Physiology and Cell Biology: Vet Med - Pulmonary cell biology and toxicology. Epithelial injury and repair. Airway remodeling in response to air pollutants (ozone, tobacco smoke, particulate matter and nanoparticles) and during postnatal lung development (naphthalene and bisphenol A). Naphthalene metabolism and toxicity.

Catherine VandeVoort, Professor in Residence, Obstetrics & Gynecology: Med - Primate reproductive physiology, including oocyte maturation, embryonic stem cells and ovarian toxicology.

Andrew Whitehead, Assistant Professor, Environmental Toxicology - Environmental, ecological, and evolutionary genomics, population genomics, conservation genetics, stress physiology, and ecotoxicology.

Lifeng Xu, Assistant Professor, Microbiology and Molecular Genetics - Telomeres are the protective nucleoprotein structures at the ends of linear eukaryotic chromosomes. Telomere dysfunction contributes to cancer progression and aging. Our laboratory employs molecular and cytological approaches to study telomere maintenance in human normal cells and cancer cells.

Qi Zhang, Associate Professor, Environmental Toxicology -